228 research outputs found
Towards improving Wikidata reuse with emerging patterns
The ontology underlying Wikidata has not been formalized. Instead, its semantics emerges from the use of its classes and properties. Flexible rules and suggestions have been defined by the Wikidata project for the use of its ontology, however, it is still often difficult to reuse the ontology's constructs. In this paper, we describe a method for extracting emerging patterns from (a domain-specific portion of) Wikidata, in the form of statistically frequent domain-property-range triplets. We show the results of our experiments on a Wikidata subset addressing the music domain, and compare them with the current support present in Wikidata. These patterns can provide guidance for the use of the Wikidata ontology and its potential improvement.</p
Entrepreneurial and market orientations: the moderating role of social networks on post-entry performance of international new ventures
This paper investigates whether entrepreneurial and marketing orientations (respectively EOs and Mos) impact – individually or collectively – international new ventures’ (INVs’) post-entry performance growth. Furthermore, we investigate whether such relations are moderated by the foreign social networks, both formal and informal, of international new ventures.
Using a survey, we test our hypotheses on a sample of Italian high-tech INVs located in a cluster near Rome. A quantitative analysis is used to test the hypotheses. We found that EOs and MOs positively impact the post-entry international performance growth of INVs. Moreover, while informal foreign social network ties significantly moderate the impact of EOs and MOs, formal foreign social network ties do not have a significant moderating effect. Many theoretical and practical contributions are discussed in the paper
Corporate ownership and internationalization: the effects of family, bank and institutional investor ownership in the UK and in Continental Europe
While the role of corporate governance has been increasingly analysed during recent years, it is only very recently that the effects of corporate governance features on firm international strategies have been also considered. Using the Osiris database by Bureau van Djik we consider the potential role played by different kind of shareholders among the determinants of firm international level, distinguishing between the firms quoted in the UK from those listed in countries of Continental Europe (France, Germany, Italy, Poland and Spain). Overall our results confirm that different kind of ownerships affect with different degree of intensity the overall level of firm'sinternationalization. First, we find that ownership matter. Second, our results show that theeffects of ownership over firm's international strategies depend also on the context of analysis
The Secret Garden of Neuronal circRNAs
High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-specific, and enriched in genes for neuronal proteins and synaptic factors. These features suggested that circRNAs are key components of an important layer of neuronal gene expression regulation, with known and anticipated functions. Here, we review major recognized aspects of circRNA biogenesis, metabolism and biological activities, examining potential new functions in the context of the nervous system
An ontology design pattern for representing recurrent situations
In this Chapter, we present an Ontology Design Pattern for representing situations that recur at regular periods and share some invariant factors, which unify them conceptually: we refer to this set of recurring situations as recurrent situation series. The proposed pattern appears to be foundational, since it can be generalised for modelling the top-level domain-independent concept of recurrence, which is strictly associated with invariance. The pattern reuses other foundational patterns such as Collection, Description and Situation, Classification, Sequence. Indeed, a recurrent situation series is formalised as both a collection of situations occurring regularly over time and unified according to some properties that are common to all the members, and a situation itself, which provides a relational context to its members that satisfy a reference description. Besides including some exemplifying instances of this pattern, we show how it has been implemented and specialised to model recurrent cultural events and ceremonies in ArCo, the Knowledge Graph of Italian cultural heritage
The Music Annotation Pattern
The annotation of music content is a complex process to represent due to its inherent multifaceted, subjectivity, and interdisciplinary nature. Numerous systems and conventions for annotating music have been developed as independent standards over the past decades. Little has been done to make them interoperable, which jeopardises cross-corpora studies as it requires users to familiarise with a multitude of conventions. Most of these systems lack the semantic expressiveness needed to represent the complexity of the musical language and cannot model multi-modal annotations originating from audio and symbolic sources. In this article, we introduce the Music Annotation Pattern, an Ontology Design Pattern (ODP) to homogenise different annotation systems and to represent several types of musical objects (e.g. chords, patterns, structures). This ODP preserves the semantics of the object s content at different levels and temporal granularity. Moreover, our ODP accounts for multi-modality upfront, to describe annotations derived from different sources, and it is the first to enable the integration of music datasets at a large scale
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.
Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA
(miRNA) precursors, with important consequences on miRNA retargeting and expression. ADAR2 activity is impaired
in glioblastoma and its rescue has anti-tumoral effects. However, how ADAR2 activity may impact the miRNome
and the progression of glioblastoma is not known.
Results: By integrating deep-sequencing and array approaches with bioinformatics analyses and molecular studies,
we show that ADAR2 is essential to edit a small number of mature miRNAs and to significantly modulate the
expression of about 90 miRNAs in glioblastoma cells. Specifically, the rescue of ADAR2 activity in cancer cells recovers
the edited miRNA population lost in glioblastoma cell lines and tissues, and rebalances expression of onco-miRNAs and
tumor suppressor miRNAs to the levels observed in normal human brain. We report that the major effect of ADAR2 is
to reduce the expression of a large number of miRNAs, most of which act as onco-miRNAs. ADAR2 can edit miR-222/221
and miR-21 precursors and decrease the expression of the corresponding mature onco-miRNAs in vivo and in vitro, with
important effects on cell proliferation and migration.
Conclusions: Our findings disclose an additional layer of complexity in miRNome regulation and provide information
to better understand the impact of ADAR2 editing enzyme in glioblastoma. We propose that ADAR2 is a key factor for
maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer
ArCo: the Italian Cultural Heritage Knowledge Graph
ArCo is the Italian Cultural Heritage knowledge graph, consisting of a
network of seven vocabularies and 169 million triples about 820 thousand
cultural entities. It is distributed jointly with a SPARQL endpoint, a software
for converting catalogue records to RDF, and a rich suite of documentation
material (testing, evaluation, how-to, examples, etc.). ArCo is based on the
official General Catalogue of the Italian Ministry of Cultural Heritage and
Activities (MiBAC) - and its associated encoding regulations - which collects
and validates the catalogue records of (ideally) all Italian Cultural Heritage
properties (excluding libraries and archives), contributed by CH administrators
from all over Italy. We present its structure, design methods and tools, its
growing community, and delineate its importance, quality, and impact
- …